Good morning. It’s August 13th, and Fast Times at Ridgemont High is now officially 43 years old, meaning Spicoli’s idea of “partying all night” now involves melatonin, magnesium, and blackout curtains.
The rundown for this week:
🧠 Alzheimer’s research finds hope in lithium levels.
👩🏽 Midi Health fills the gaps for women 40+
🌎 We’ve hit the ceiling globally on lifespan (for now…)
🧬 The Human Phenotype Project hits another milestone.
Let’s get to it. 👇
CNN - Pick up the pace! Fast walking is a key to longevity, research shows. (Read more)
Forbes - Celine Halioua opens the curtain behind her $135M dog longevity start-up. (Read more)
The New York Post - Athletes and biohackers love this restorative, red-therapy chamber. (Read more)
MSNBC - How ultra-processed foods impact your lifespan. (Watch video)
The Indepedent - Life expectancy around the world has stalled. Here’s what's causing the plateau. (Read more)
GQ - The best morning routine, according to health experts. (Read more)
Zime Science- Resistance training can trigger your body’s internal anti-aging switch. (Read more)
FROM THE CLINIC
Study Finds Lithium Could Reverse Cognitive Decline
The future you might be chasing your creatine pills with a lithium smoothie to avoid the grim reaper.
That same mineral powering EV batteries.
Kinda gross? But kinda rad.
Researchers found that topping up the brain’s natural lithium might not just slow Alzheimer’s, but actually reverse memory loss.
Here’s the 411 on their findings:
Lithium depletion in the brain is linked to increased amyloid plaques and tau tangles (hallmarks of Alzheimer’s) The disease sets up a feedback loop: low lithium → more plaques → even lower lithium.
Lithium carbonate, a common supplement, binds to plaques and becomes trapped, reducing effectiveness.
Lithium orotate avoids plaque entrapment and can distribute more effectively through brain tissue.
In mouse models of Alzheimer’s, low doses of lithium orotate restored normal lithium levels, reduced plaques/tangles, and improved cognitive performance. 🎉
It’s early days (no, don’t start popping lithium pills just yet), but researchers might be onto something here.
IN THE NEWS
OneSkin Bags $20M to Slow the March of Time
Skin longevity brand OneSkin just landed $20M in funding from Prelude Growth Partners, with a goal of extending your “skinspan” by keeping skin healthy and youthful at the cellular level.
Their key ingredient is OS-01, a peptide designed to reduce aging cells that drive inflammation and collagen loss.
The brand already counts Jennifer Aniston, Katy Perry, and Camila Alves McConaughey among its notable users.
IN THE NEWS
This Is 40 (In Your Medicine Cabinet)
Midi Health—the virtual clinic for women in midlife—just introduced their debut line tailored for ages 40+. These formulas fill a critical gap in midlife wellness, targeting cognitive support, stress relief, metabolic health, and weight control. Based on insights from over 200,000 patient visits, each product delivers evidence-backed ingredients in effective doses.
The initial lineup includes:
Daily Fiber+ – a gummy with soluble corn fiber, green banana powder, and chromium picolinate, aiming to support digestion, stabilize blood sugar, and curb cravings.
Daily Cortisol Support – capsules with magnesium glycinate, L‑theanine, ashwagandha, phosphatidylserine, and magnolia bark to promote calm focus, better sleep, and emotional resilience.
Daily Brain Boost – packed with methylcobalamin B12, choline, and CoQ10 to sharpen clarity, memory, and energy levels.
The Human Phenotype Project rolls on as a MASSIVE, long-term health study with the goal of building the most detailed health database ever, with 28,000 partipants currently enrolled.
They collect everything (genes, microbiomes, diet, sleep, blood tests, imaging, wearables) and follow participants for decades.
The end goal?
Use AI to spot early warning signs of disease, redefine what “normal” health looks like, and create super-personalized medicine.
And it’s working…👇🏼
Excited to share a milestone published in @NatureMedicine from our decade-long effort to build The Human Phenotype Project, a unique longitudinal cohort with unmatched depth of clinical and multi-omic profiling, enabling truly predictive, personalized medicine.
Led together with
— #Eran Segal (#@segal_eran)
4:19 PM • Jul 16, 2025
