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Good morning. It’s August 6th, and hollywood has rebooted The Naked Gun; a reminder that some things might be better off left dead. (RIP to the OG, Leslie Nielsen).
The rundown for this week:
🫀 A breakdown of organ aging.
💉Ozempic is back in the headlines, this time with promising results.
🧴 Martha Stewart still carving a career path at 84.
😞 The link between grief and health.
Let’s get to it. 👇
ABC News - Martha Stewart, at 84 years young, debuts first skincare line. (Read more)
Today Show - 5 simple longevity tips from a 101-year old woman athlete. (Read more)
CBS News - Maryland unveils landmark state plan, “Longevity Ready Maryland”, to support a thriving aging population. (Read more)
Business Insider - 4 food rules to stay in shape and live longer, according to this doctor. (Read more)
Athletech - The States with the longest life expectancy might surprise you. (Read more)
The Independent - Injectable peptides are trending with middle-aged men, but is it a dangerous gamble? (Read more)
GQ - How to improve your grip strength, and why it matters for health optimization. (Read more)
inc.com - Coastal living linked to longer lifespans, according to this Ohio State University study. (Read more)
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FROM THE CLINIC
Researchers Uncover Rhythmic Bursts of Aging
A new study is flipping the script on how we think about aging.
Scientists analyzed blood samples from nearly 45,000 people to build a test that estimates the biological age of 11 different organs, showing which parts are aging faster than your birth certificate says.
The researchers used data from the UK Biobank, which has tracked the health of 40 to 70 year olds for up to 17 years. By analyzing blood proteins, they created average profiles for what a 40-year-old liver or a 70-year-old artery looks like, then used those profiles to spot who’s aging fast, and who’s aging well.
Their findings show that biological aging isn’t a slow, steady drip like we thought. Instead, it’s more like a light switch, flipping on in sudden bursts. These “aging spurts” seem to come in waves, rather than gradually over time.
Turns out, your organs don’t all age in sync. A few key findings:
The spleen, aorta, and adrenal glands start showing signs of wear as early as age 30.
The aorta (your body’s main artery) gets hit especially hard, with major shifts in protein levels around ages 45 and 55.
While you’re worrying about wrinkles, your internal wiring may already be aging behind the scenes (and not at the same pace).
Ages 45 to 55 were where the most significant changes happened.
This group saw sharp biological age spikes, aka “aging surges.”
Your body may look fine, but under the hood, the organs are aging at their own pace.
Over 55?
Changes slow down again, and aging becomes more gradual across the body system.
This study challenges one of our deepest assumptions about aging: that it’s a slow, linear process.
If aging comes in bursts, then the choices you make during those bursts might matter more than ever.
The next frontier might be learning when and how to reset your internal organ clocks.
FROM THE CLINIC
Ozempic Reverses Biological Age In First Clinical Trial
What if your weekly weight loss shot could do more than shrink your waistline, like literally turn back time?
A randomized controlled trial of 108 people with HIV-associated lipohypertrophy found that weekly Ozempic (semaglutide) over 32 weeks reversed participants’ biological age by an average of 3.1 years.
And some bonus points; aging in the inflammatory system and brain was delayed by nearly 5 years.
Researchers used epigenetic clock analyses to track changes and attribute the effects mainly to improved fat distribution and reduced inflammation. Although participants had HIV-related metabolic changes, this study suggests the mechanisms likely apply more broadly, indicating potential anti-aging benefits beyond diabetes and weight loss
The body of evidence linking mental health to physical outcomes continues to grow.
Grief may be even deadlier than we all thought.
Within 24 hours of losing someone you love, your risk of experiencing a heart attack increases by more than 2,000%, a startling statistic from Dr. Keith Sakata, highlighting how mental health and/or trauma can put your body at serious physical risk.
What’s happening here?
Grief triggers a massive surge of stress hormones (like cortisol and adrenaline), immune activation, and inflammation. These physiological changes can strain the cardiovascular system, sometimes leading to what's known as “broken heart syndrome” or stress-induced cardiomyopathy.
Food for thought as we all ride the rollercoaster and manage life’s unexpected twists and turns.👇🏼
In the 24 hours after losing someone you love, your risk of a heart attack spikes by over 2000%.
A stark reminder: grief isn’t just emotional. It floods your body with adrenaline, cortisol, inflammation, and clotting factors.
— #Keith Sakata, MD (#@KeithSakata)
12:41 PM • Aug 3, 2025
