Wall Street Journal - The longevity business is booming — and some scientists are clashing. (Read more)

Women’s Health - Jump-training, aka high-impact, helps build strength, resilience, and longevity for women later in life. (Read more)

Inc. - Go inside a new longevity program at the famed Canyon Ranch resort, where stressed-out founders spend $20k on treatments. (Read more)

Gizmodo - Test subjects for Bryan Johnson’s anti-aging program of 1,700 people are reporting feeling sick. (Read more)

The Telegraph - Pig brains and oxygen chambers; how the super rich are biohacking. (Read more)

STORY OF THE WEEK

🧬 23andMe’s GENETIC GAMBLE GOES BUST

The once-gleaming promise of personalized genomics, epitomized by 23andMe, has dimmed considerably.

The company, which once held the keys to our very genetic blueprints, is now navigating the treacherous waters of bankruptcy, a stark reminder that even the most innovative ventures are not immune to the cold realities of the market.

And now it’s time for the private equity goon squad to swarm in. Oy, vey. 🫠

23andMe was originally founded on the premise of democratizing genetic information, allowing individuals to peer into their ancestral past and potential health predispositions with a simple saliva sample. The idea was compelling: to empower individuals with knowledge about their own biology.

That whole privacy and DNA thing though….it became a bit messy over the years.

The company's business model, reliant on consumer interest and subscription revenue, proved vulnerable to shifting market dynamics and growing privacy concerns.

So what’s next? We’re not quite sure, but there’s a whole lot of genetic data up for grabs, and we hope it lands in the right hands.

Continue reading the full story

DEEP DIVE SESSION

💊 101 DISCUSSION ON NAD+

Is it time to toss your acai berries and your kale smoothies in the garbage?

The new darling of the wellness set is NAD+, or nicotinamide adenine dinucleotide.

But is this molecule the fountain of youth we've been searching for, or just another fleeting trend in the supplement saga?

Let’s start with the basics - What is NAD+?

NAD+ is essentially a helper molecule, facilitating redox reactions within cells. It's vital for converting nutrients into energy, repairing damaged DNA, and maintaining cellular function.

As we age, NAD+ levels decline, a fact that has not escaped the attention of those who see aging as a solvable engineering problem. This drop is theorized to contribute to various age-related declines, from cognitive impairment to muscle weakness.

What’s the hype?

It’s all about NAD+’s anti-aging benefits.

Studies, often conducted on model organisms, have shown promising results. Research published in Cell Metabolism demonstrated that boosting NAD+ levels in mice improved mitochondrial function and muscle health. More relevant to human application, some preliminary human studies have shown that NAD+ precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) can increase NAD+ levels in humans.

Let’s break down where it sees the most impact:

• Cognitive Function: Increased NAD+ levels may reduce nerve cell inflammation, potentially mitigating age-related cognitive disorders such as Parkinson's disease.

• Cardiovascular Health: NAD+ precursors can lead to a mild reduction in blood pressure and arterial stiffness in middle-aged and older adults, suggesting a positive impact on heart health.

• Metabolic Function: Supplementation with NAD+ precursors has been associated with improved muscle insulin sensitivity and enhanced insulin signaling, which are crucial factors in metabolic health.

Where do we go from here?

The long-term effects of NAD+ supplementation are still largely unknown, and the field is rife with conflicting findings and exaggerated claims.

You’ve probably seen Dr. David Sinclair of Harvard Medical School, a prominent advocate of NAD+ precursors, talking up the latest product or research.

There’s a LOT of hype right now. And with hype, comes a lot of imitations, and potentially shady characters. We know this all too well in the supplement space.

Learn more about 11 brands competing in the NAD+ space, and do your research!

Get your podcast fix in with our March 2025 Top 25 list of the best conversations on all things longevity and health.