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Hello. It's June 25.
Most supplement labels tell you what to take more of. They rarely tell you what to take less of.
A study of 270,000 people just put tyrosine - a popular amino acid supplement sold for focus and energy - on the wrong side of the ledger. At least for men.
Let's get into it.
The rundown for this week:
💊 A study of 270,000 people links a popular focus supplement to shorter lifespans in men
🌊 Nordic Wave vs Plunge vs The Cold Life: the cold plunge verdict for 2026
📍 Longevity's biggest summer conference is happening right now in Dublin
🔵 Oura Ring 5 just launched with blood pressure monitoring and GLP-1 insights
Let's get to it. 👇
The best exercise combo for longevity is resistance training + cardio, backed by a 30-year study - just 90-120 minutes of strength training per week linked to a significantly lower death risk. Combined with cardio, the effect compounds further. SciTechDaily
A wearable cortisol sensor can now track stress hormones continuously across multiple days - Adaptyx Biosciences presented data on a device that reads free cortisol levels in real time. Chronically elevated cortisol is linked to accelerated aging and poor sleep. Longevity.Technology
An Alzheimer's biomarker may affect how hormone therapy changes dementia risk - new research shows amyloid-beta status interacts with hormone therapy outcomes in ways that could change prescribing decisions for millions of midlife women. SciTechDaily
Elysium Health just launched TELI - a physician-led longevity care platform - biomarker testing, physician oversight, supplements, prescriptions, and peptides in one integrated program. The clearest sign yet that the supplement brand is pivoting toward full clinical care. Longevity.Technology
UC Riverside engineers an oxygen-delivery gel for chronic wounds that can't reach damaged tissue - oxygen deprivation is why chronic wounds spiral out of control. This gel delivers a continuous supply directly into the deepest layers of injured tissue. ScienceDaily
FROM THE CLINIC
The Supplement Nobody Warned You About
Here's a sentence you don't read often: a supplement may be shortening lifespans.
A new study published in the journal Aging, drawing on health and genetic data from over 270,000 people in the UK Biobank, found that men with genetically higher levels of tyrosine in their blood appeared to live nearly one year less on average. Women showed no statistically clear association.
Tyrosine is an amino acid - one of the building blocks your body uses to make proteins, as well as key brain chemicals like dopamine and adrenaline, the chemicals that control focus, drive, and the body's stress response. It's found naturally in eggs, meat, dairy, and soy. It's also widely sold as a standalone supplement for mental focus and cognitive performance under pressure.
The science breakdown:
Researchers used Mendelian randomization - a technique that uses inherited genetic differences to estimate whether a biological factor directly influences a health outcome, rather than just correlating with it
Both tyrosine and its precursor phenylalanine initially appeared linked to shorter lifespan
After accounting for the overlapping effects between the two, only tyrosine retained a statistically significant association
In men, genetically higher tyrosine was linked to a lifespan reduction of approximately 0.9 years
The sex difference is unexplained; estrogen's interaction with amino acid metabolism is a candidate being explored
Published in Aging by researchers from University of Hong Kong and University of Georgia
Important caveats: this is an observational study using a genetic proxy for tyrosine levels - not a clinical trial. The finding raises a flag; it doesn't prove causation. But if you currently take tyrosine for focus or stress, this is a good reason to ask your doctor whether you actually need it.
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LONGEVITY BIZ
Where the Longevity Field is Heading To
The Longevity Summit Dublin is in full swing. It runs June 24-26 at Trinity College Dublin - one of the most concentrated gatherings of longevity scientists, clinicians, and investors on the annual calendar.
Why does a conference matter? Because this is where the field's consensus shifts. Where data gets presented before it hits journals. Where deals get done.
A few things to watch from this year's agenda:
The push to establish longevity medicine as a recognized clinical specialty - this is where serious institutional capital is flowing
Presentations on biological age clocks and how close the field is to using them as regulatory endpoints - the key to getting longevity drugs approved without waiting for people to actually die in trials
Increasing crossover between AI drug discovery platforms and aging biology
The big unanswered question: how does longevity medicine get paid for at scale, by healthcare systems rather than just wealthy individuals?
Longevity used to be a fringe conversation at mainstream medical conferences. Now it has its own conferences, journals, specialty training programs, and investment funds. Dublin is a useful annual barometer of how fast that institutionalization is actually moving.
CHECK YOUR STACK
❄️ Cold Plunges Compared (2026):
Nordic Wave vs Plunge vs The Cold Life ❄️
Cold water immersion has earned its place in the longevity toolkit. The research on cold exposure - improved recovery, better stress resilience, cardiovascular benefits, and a measurable boost in norepinephrine (a neurotransmitter involved in focus, mood, and alertness) - is solid enough that the question has shifted from "should I cold plunge?" to "which tub is worth the money?"
Here's the ultimate 2026 ice tub comparison.
The Cold Life Ultimate - avoid
Claims "3,000+ five-star reviews." Verified count: a couple hundreds
Consistent reports of leaking tubs and daily condensation puddles
Chillers may fail within 3-6 months. Warranty claims and customer service reportedly denied.
No app, no smart features.
This ice tub does fit tall people, but it’s heavy to move around.
Plunge All-In / Pro - solid second place
Great filtration, stable temperature, good reviews
Easily control the ice tub with the Plunge app
Premium acrylic build, spacious interior, and ability to be used both indoors and outdoors.
Heating is a $500 add-on, pushing total cost to $5,490-$9,500+
Nordic Wave Viking - the frontrunner
The fastest to cool down to 35°F; heat built-in (not a $500 add-on) to 104°F
Built in a former Yeti factory, marine-grade construction
5-year warranty on the tub vs 1 year for both competitors
Comes with breathwork app, guided by Wim Hof-trained coaches
4.8/5 across 1,000+ verified reviews. All-in price: $4,500-$7,490
The verdict: Plunge is a famous brand offering a premium experience; if you prefer a horizontal plunge position, go for Plunge. But if you prefer a 5-year warranty (vs. 1 year), don’t mind sitting upright (Viking mode), and don’t want to break the bank, the Nordic Wave Viking has the best price/quality ratio in 2026.
IN THE NEWS
Oura Ring 5: Unlike the iPhone Drop, Things Actually Changed 🔵
Most tech refreshes add a new color and call it a redesign. Oura went the other direction - they rebuilt the Ring 5 from scratch. Here's what's actually different:
40% smaller and thinner than Ring 4, completely re-engineered to look and feel like standard jewelry rather than a piece of wellness tech
Battery actually increased despite the smaller form factor - 6 to 9 days on a single charge, up from the previous generation
Nighttime blood pressure tracking patterns - tracked continuously while you sleep, where blood pressure tells you things your daytime cuff readings miss
Breathing monitoring and sleep apnea detection - proactive flags before you ever sit in a sleep specialist's office
GLP-1 drug insights - the first wearable to specifically account for users on semaglutide or tirzepatide, which change how HRV, sleep, and metabolic data should be interpreted
"Health Radar" in the upgraded companion app - a synthesized view that ties your metrics together rather than presenting them as isolated data streams
The broader trend: wearables are no longer fitness trackers. They're becoming the layer between your body and your doctor. Ring 5 is the most convincing version of that argument yet.
BIOHACK BOOKS
The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer
Elizabeth Blackburn & Elissa Epel
A Nobel Prize was awarded for discovering exactly how stress ages your cells - down to the molecular level. This is that book.
The central idea: telomeres - the protective caps on the ends of your chromosomes, think of them as the plastic tips on shoelaces that keep them from fraying - shorten every time a cell divides. Most people assume this is a fixed biological clock. Blackburn and Epel show it's more like a dial. The way you handle stress, sleep, move, and connect with other humans is turning it every single day.
What makes this book stand apart is that it bridges mechanism and practice without dumbing either down. You'll leave understanding why that relentlessly stressful year wasn't just emotionally hard - it left a measurable biological trace. And you'll know what to do about it.
GET IN FRONT OF 24K LONGEVITY READERS
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